budipine

Budipine is a small molecule antiparkinsonian agent used for the treatment of Parkinson's disease. It is particularly effective in reducing parkinsonian tremor and provides additional benefit when added to standard dopaminergic regimens. The exact mechanism of action is not fully characterized but includes antagonism at NMDA receptors and weak antimuscarinic activity. Budipine also influences dopamine biosynthesis by inhibiting monoamine oxidase B (MAO-B) and stimulating aromatic L-amino acid decarboxylase, as well as inhibiting dopamine reuptake. Additionally, it may modulate GABAergic, noradrenergic, serotonergic, and cholinergic neurotransmission. It crosses the blood-brain barrier and is metabolized primarily by hydroxylation[5][7][8][9][10].

Brand names

Parkinsan

Other names

1-tert-butyl-4,4-diphenylpiperidineBudipinBudipine hydrochloride