buguzhi total glycosides

Buguzhi total glycosides is a standardized botanical extract derived from the seeds of *Psoralea corylifolia* L. (Buguzhi), a traditional Chinese medicinal herb. Developed by the Jiangsu Provincial Academy of Traditional Chinese Medicine, this pharmaceutical candidate is specifically formulated for the treatment of primary osteoporosis. The extract is enriched with bioactive glycosides and flavonoids that function as phytoestrogens. Its mechanism of action involves the modulation of bone metabolism by promoting osteoblast differentiation and bone formation while simultaneously inhibiting osteoclast-mediated bone resorption. These effects are primarily mediated through the activation of estrogen receptors (ERα and ERβ) and the stimulation of the Wnt/β-catenin signaling pathway, leading to improved bone mineral density and strengthened bone microarchitecture.

Other names

Psoralea corylifolia total glycosidesTotal glycosides of Psoralea corylifoliaBuguzhi Zonggan补骨脂总苷