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Bujing Yishi
- Development stage
- Unknown
- Lead developer
- Hospital of Chengdu University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Bujing Yishi is a Traditional Chinese Medicine (TCM) formulation developed by the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, primarily used for the treatment and prevention of myopia in children and adolescents. The formulation is based on the TCM principle of tonifying the liver and kidney essence to nourish the eyes and improve visual function. Clinical and preclinical research suggests that Bujing Yishi may slow the progression of myopia by inhibiting axial length elongation. Its biological activity is associated with the modulation of scleral remodeling, specifically through the regulation of growth factors and enzymes such as transforming growth factor-beta (TGF-β) and matrix metalloproteinases (MMPs) in the ocular tissues. It is typically administered as an oral granule and is currently utilized as a hospital-made preparation (院内制剂) while undergoing further clinical evaluation.
- Brand names
- Bujing Yishi Granules
- Other names
- Bujing Yishi KeliBujing Yishi Formula补精益视颗粒
02
Targets
TGFB2 (Transforming growth factor beta 2)MMP2 (Matrix metalloproteinase-2)
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