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Bultavo 3 is an inactivated, adjuvanted vaccine developed for the active immunisation of sheep and cattle against bluetongue virus serotype 3 (BTV-3). The vaccine contains inactivated bluetongue virus serotype 3 (strain Bio-93:BTV3) as the active ingredient, with aluminium hydroxide and Quillaja saponin (Quil A) as adjuvants. It is administered subcutaneously in sheep (single dose) and intramuscularly in cattle (two doses three weeks apart). The vaccine has been shown to significantly reduce viraemia and prevent mortality and clinical signs associated with BTV-3 infection. Onset of immunity occurs three weeks after administration. Developed rapidly in response to recent outbreaks of BTV-3 across Europe, it is the first licensed vaccine specifically targeting this serotype[1][4][5][10].
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