Drug intelligence / Profile preview

bumetanide

Development stage
Approved
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral, Intravenous, Intramuscular
01

Overview

Bumetanide is a potent loop diuretic (water pill) used primarily to treat edema (fluid retention) associated with congestive heart failure, liver disease, kidney disease, and nephrotic syndrome. It acts by inhibiting sodium and chloride reabsorption in the ascending limb of the loop of Henle in the kidney, leading to increased excretion of water, sodium, chloride, and potassium. This results in diuresis and reduction of fluid overload. Bumetanide is considered more potent than furosemide on a per-milligram basis and has more predictable pharmacokinetics. It is available as oral tablets or injectable solutions[1][5][8].

Brand names
BumexBurinex
Other names
RSQ-777RSQ777RSQ 777bumetanide nasal sprayBNS
02

Targets

NKCC2 (Sodium-potassium-chloride cotransporter 2)

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