bunazosin

Bunazosin is a small molecule, quinazoline derivative that acts as a selective alpha 1 adrenergic receptor antagonist. It was originally developed for the treatment of benign prostatic hyperplasia and hypertension, and has also been approved in Japan in topical form for the treatment of glaucoma and ocular hypertension. Its mechanism of action involves blocking alpha 1 adrenergic receptors, leading to vasodilation and reduced blood pressure systemically, while in ophthalmic use it lowers intraocular pressure by increasing uveoscleral outflow. The drug has been marketed under several brand names including Andante and Detantol[1][2][3][5][6][7].

Brand names

AndanteDetantol

Other names

bunazosin hydrochlorideBunazosinumBunazosinaBunazosinebunazocine