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BunyaVax 4s
- Development stage
- Preclinical
- Lead developer
- Bunyavax
- Modality
- Live Attenuated Vaccines → Live Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Subcutaneous
01
Overview
BunyaVax 4s is a live-attenuated vaccine platform developed by Bunyavax, specifically targeting the Rift Valley fever virus (RVFV). The technology utilizes a unique four-segmented genome approach where the M genome segment of the virus is split into two distinct M-type segments. This modification ensures complete safety, even in pregnant animals, while maintaining high immunogenicity. The vaccine is being developed for both veterinary use (sheep, goats, and cattle) and human use, with the human program (LARISSA project) receiving funding from CEPI. It primarily targets the Gn and Gc glycoproteins of the RVFV to induce protective immunity.
- Other names
- LarissaLARISSA vaccine
02
Targets
GC (Vitamin D-binding protein)Gn (Hantaan virus glycoprotein Gn)
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