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bupivacaine + adrenaline (IPACK block)
- Development stage
- Unknown
- Lead developer
- Kırşehir Ahi Evran Üniversitesi
- Modality
- Small Molecules
- Administration
- Infiltration
01
Overview
A specific regional analgesic intervention developed and studied by Kirsehir Ahi Evran Universitesi for the management of postoperative pain in patients undergoing total knee arthroplasty (TKA). The intervention consists of an IPACK (Infiltration between the Popliteal Artery and the Capsule of the Knee) block, which utilizes a combination of 0.25% bupivacaine (Marcaine) and 2.0 μg/mL of adrenaline (epinephrine) in 0.9% saline. Administered under ultrasound guidance, the solution is injected into the anatomical space between the popliteal artery and the posterior capsule of the knee. This technique is designed to provide targeted analgesia to the posterior aspect of the knee joint by blocking terminal sensory branches without inducing motor blockade of the sciatic nerve, thereby facilitating earlier rehabilitation and functional recovery.
- Brand names
- Marcaine
- Other names
- IPACK blockInfiltration between the Popliteal Artery and the Capsule of the Knee
02
Targets
NaV (Voltage-gated sodium channels)ADRA1A (α1A)
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