bupivacaine + dextrose

Bupivacaine + dextrose is a hyperbaric formulation of the amide-type local anesthetic bupivacaine, typically containing 0.75% bupivacaine hydrochloride and 8.25% dextrose. This combination is specifically designed for spinal (intrathecal) anesthesia. Bupivacaine acts as a potent local anesthetic by binding to the intracellular portion of voltage-gated sodium channels, thereby blocking sodium influx into nerve cells and preventing the generation and conduction of nerve impulses. The addition of dextrose increases the density (baricity) of the solution relative to cerebrospinal fluid (CSF), making it hyperbaric. This allows the anesthetic to settle in dependent areas of the spinal canal under the influence of gravity, providing a more predictable and controlled regional block. The University of Manitoba has investigated this formulation in high-spinal anesthesia protocols for patients undergoing elective liver resection surgery to manage postoperative pain and facilitate enhanced recovery after surgery (ERAS).

Brand names

Marcaine Spinal

Other names

hyperbaric bupivacainebupivacaine 0.75% in dextrose 8.25%Bupivacaine 0.75% in Dextrose Inj 8.25%