bupivacaine + epinephrine + dexamethasone (University of Calgary)

Dexamethasone-University of Calgary-pain (postoperative) refers to a specific regional anesthesia protocol utilizing a combination of **bupivacaine**, **epinephrine**, and **dexamethasone** administered via an iPACK (Infiltration between the Popliteal Artery and Capsule of the Knee) block. Developed and studied by the **University of Calgary** in a Phase 4 clinical trial (NCT04635176), this formulation is designed to manage posterior knee pain following total knee arthroplasty. Dexamethasone (specifically a 50 mcg/mL preservative-free formulation) serves as a perineural adjuvant intended to prolong the analgesic effect of the local anesthetic bupivacaine, while epinephrine acts as a vasoconstrictor to limit systemic absorption and further extend the block duration. This multimodal approach aims to provide effective sensory blockade to the posterior aspect of the knee joint while preserving motor function in the lower extremity.

Other names

dexamethasone-University of Calgary-pain (postoperative)iPACK block solutioniPACK block with dexamethasone