bupivacaine + fentanyl (Mansoura University)

This specific epidural analgesia regimen, utilized in clinical research at Mansoura University, consists of a combination of the amide-type local anesthetic bupivacaine (0.125%) and the synthetic opioid fentanyl (2 μg/ml). It is administered via continuous epidural infusion at a rate of 8-15 ml/hr to provide pain relief during normal labor. Bupivacaine acts by binding to the intracellular portion of voltage-gated sodium channels, blocking sodium influx and inhibiting the propagation of action potentials in nerve fibers. Fentanyl complements this by acting as a potent agonist at mu-opioid receptors in the central nervous system, particularly within the substantia gelatinosa of the spinal cord, thereby modulating pain transmission and providing regional analgesia.

Other names

Epidural analgesiaBupivacaine-fentanyl epiduralContinuous epidural analgesia