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bupivacaine + hydromorphone
- Development stage
- Unknown
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Intrathecal
01
Overview
A combination medication consisting of bupivacaine, an amide local anesthetic, and hydromorphone, an opioid analgesic. This combination is primarily used in intrathecal (IT) drug delivery systems for managing chronic pain, particularly in patients with failed back surgery syndrome (FBSS) or post-laminectomy syndrome. The combination has shown effectiveness in reducing pain intensity and oral opioid consumption, with bupivacaine helping to attenuate the opioid dose escalation phenomenon commonly observed with intrathecal opioid monotherapy.
- Other names
- Thoracic Epidural AnalgesiaTEAThoracic Epidural Analgesia-Masonic Cancer Center, University of Minnesota-postoperative pain
02
Targets
NaV (Voltage-gated sodium channels)MOR (Mu opioid receptor)
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