bupivacaine + levobupivacaine

**Bupivacaine + levobupivacaine** denotes a putative combination of two long-acting amino-amide local anesthetics. Bupivacaine is the racemic drug substance, whereas levobupivacaine is its single S-enantiomer; consequently, this combination would add levobupivacaine to a preparation already containing the S-enantiomer as part of racemic bupivacaine. Both agents reversibly and use-dependently inhibit voltage-gated sodium channels in peripheral nerves, suppressing action-potential initiation and propagation to produce local or regional anesthesia and analgesia. No specific marketed, registered clinical-development, or standardized co-formulated product containing exactly these two active ingredients was identified.

Other names

bupivacain + levobupivacaine