Drug intelligence / Profile preview

bupivacaine + lidocaine (Cukurova University)

Development stage
Phase 4
Lead developer
Cukurova University
Modality
Small Molecules
Administration
Local Injection
01

Overview

ESP-Cukurova University-postoperative pain refers to a regional anesthetic intervention utilizing a combination of the local anesthetics **bupivacaine** and **lidocaine** administered via an ultrasound-guided erector spinae plane (ESP) block. Developed and evaluated by **Cukurova University**, this technique involves the injection of local anesthetics into the fascial plane deep to the erector spinae muscle and superficial to the transverse processes of the vertebrae. The primary indication for this intervention is the management of postoperative pain, particularly in patients undergoing lumbar spinal surgery or total mastectomy. The mechanism of action involves the blockade of voltage-gated sodium channels in the dorsal and ventral rami of spinal nerves, effectively interrupting the transmission of pain signals and providing regional analgesia. Clinical trials conducted by Cukurova University have compared this technique against standard care or other regional blocks (such as the serratus anterior plane block) to assess its efficacy in reducing postoperative opioid consumption and pain scores.

Other names
ESP blockErector spinae plane blockUSG Guided ESP Block
02

Targets

SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)

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