bupivacaine + morphine (Shaare Zedek Medical Center)

Bupivacaine + morphine is a combination drug regimen evaluated by Shaare Zedek Medical Center for the management of postoperative pain in pediatric patients. This combination is administered via the caudal route, primarily for children undergoing renal surgery. Bupivacaine, a local anesthetic of the amide type, functions by binding to and blocking voltage-gated sodium channels on the neuronal membrane, thereby preventing the generation and conduction of nerve impulses. Morphine, a potent opioid analgesic, acts as an agonist at mu-opioid receptors within the central nervous system, including the spinal cord, to provide prolonged and synergistic pain relief. The Phase 4 study (NCT01141309) specifically evaluates the efficacy and safety of adding morphine to standard bupivacaine caudal blocks to improve postoperative outcomes in this specific surgical population.

Brand names

Marcaine

Other names

Morphine-supplemented caudal anesthesiaCaudal bupivacaine with morphineCaudal anesthesia supplemented with morphine