bupivacaine + saline

The combination of bupivacaine and saline is a pharmacological preparation used primarily as a local anesthetic and as a control intervention in clinical research. Bupivacaine is a long-acting amide-type local anesthetic that functions by binding to the intracellular portion of voltage-gated sodium channels. This binding stabilizes the neuronal membrane and inhibits the ionic fluxes required for the initiation and conduction of nerve impulses, effectively blocking pain signals. In the context of clinical trials conducted by Tanta University, this specific formulation (typically 29 ml of 0.25% bupivacaine mixed with 1 ml of 0.9% saline) is administered via regional techniques such as the external oblique intercostal plane (EOIP) block to manage post-thoracotomy pain. Saline serves as an isotonic vehicle and diluent, often used to match the volume of an active adjuvant being tested in the experimental arm of a study.

Other names

29 ml bupivacaine 0.25% + 1 ml saline