Drug intelligence / Profile preview

bupivacaine + triamcinolone + sodium chloride

Development stage
Unknown
Lead developer
AstraZeneca
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Intraarticular, Intramuscular, Epidural, Perioperative
01

Overview

This is a compounded combination drug consisting of bupivacaine, triamcinolone (typically as the acetonide), and sodium chloride. - **Bupivacaine** is an amide-type local anesthetic that blocks voltage-gated sodium channels in neuronal membranes, preventing nerve impulse transmission and providing local or regional anesthesia[3][4][6]. - **Triamcinolone** is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties; it acts by binding to glucocorticoid receptors, modulating gene expression to suppress inflammation[8]. - **Sodium chloride** serves as an isotonic diluent or vehicle for injection. This combination is used primarily for pain management in procedures such as intra-articular injections or perioperative analgesia (e.g., after lumbar discectomy), where the local anesthetic provides immediate pain relief and the corticosteroid reduces inflammation over time[2][5]. The addition of sodium chloride ensures isotonicity for safe tissue administration.

02

Targets

GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)PTGER1 (Prostaglandin E Receptor 1)

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