bupivacaine 0.5%

Bupivacaine 0.5% is a local anesthetic solution belonging to the amide class of local anesthetics, with bupivacaine hydrochloride as its active ingredient. It is commonly marketed under brand names such as Marcaine and Sensorcaine. Bupivacaine works by blocking voltage-gated sodium channels in neuronal cell membranes, thereby inhibiting the initiation and conduction of nerve impulses and producing local anesthesia and analgesia. In the context of the University of Rochester clinical trial, bupivacaine 0.5% was evaluated as a continuous intraarticular and/or patellar tendon site infusion via catheter for the management of postoperative pain following anterior cruciate ligament (ACL) reconstruction — a randomized, placebo-controlled study. It is a small molecule drug and is FDA-approved for various anesthetic indications, though its use in continuous intraarticular infusion for ACL postoperative pain represents a specific investigational application in this trial context.

Brand names

MarcainMarcaineSensorcaine

Other names

Bupivicaine 0.5%bupivacaine HCl 0.5%bupivacaine hydrochloride 0.5%