bupivacaine liposome + bupivacaine hydrochloride

SKY0402 + bupivacaine refers to the combination or co-administration of liposomal bupivacaine (SKY0402, brand name Exparel) and conventional bupivacaine hydrochloride. SKY0402 is an extended-release formulation developed by Pacira Pharmaceuticals that utilizes the proprietary DepoFoam multivesicular liposome technology to encapsulate bupivacaine, allowing for a slow release and prolonged analgesic effect for up to 72 hours. In clinical practice, conventional bupivacaine HCl is often mixed with or administered alongside SKY0402 to provide a rapid onset of anesthesia, compensating for the slower onset of the liposomal formulation. This combination is primarily indicated for postoperative pain management via local infiltration or regional nerve blocks. The specific trial context provided describes a Phase 2 study in women undergoing bilateral augmentation mammoplasty, comparing the efficacy and safety of SKY0402 against conventional bupivacaine HCl for prolonged postoperative analgesia.

Brand names

Exparel + bupivacaine

Other names

liposomal bupivacaine + bupivacaine HClDepoBupivacaine + bupivacaine