bupivacaine liposome suspension

Bupivacaine liposome suspension is an extended-release formulation of the amide-type local anesthetic bupivacaine. It utilizes the DepoFoam multivesicular liposome technology to encapsulate bupivacaine, allowing for a slow release of the drug over an extended period, typically providing analgesia for up to 72 hours. Developed by Pacira BioSciences, it is primarily indicated for single-dose infiltration into the surgical site to produce postsurgical local analgesia and for various nerve blocks (e.g., interscalene brachial plexus block, sciatic nerve block) to provide regional analgesia. Its mechanism involves blocking voltage-gated sodium channels on the internal surface of nerve cell membranes, thereby preventing the generation and conduction of nerve impulses.

Brand names

Exparel

Other names

bupivacaine liposome injectable suspensionliposomal bupivacainebupivacaine liposome