Drug intelligence / Profile preview

bupleurum plus dragon bone and oyster shell decoction + sertraline

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination therapy consisting of "Bupleurum plus Dragon Bone and Oyster Shell Decoction" (a traditional Chinese herbal formula also known as Chai Hu Jia Long Gu Mu Li Tang) and the pharmaceutical antidepressant "sertraline." The herbal decoction is traditionally used in East Asian medicine to calm the spirit, harmonize Shao Yang, unblock the three Yang stages, move liver Qi, clear heat, subdue liver yang, dissolve phlegm, tonify righteous Qi, and promote mental well-being. Its ingredients include Bupleurum root (Chai Hu), Pinellia rhizome (Ban Xia), Poria (Fu Ling), Cinnamon twig (Gui Zhi), Chinese skullcap (Huang Qin), Jujube fruit (Da Zao), Ginger (Sheng Jiang), Ginseng root (Bai Shen or Dang Shen), Dragon's bone (Long Gu), Oyster shell (Mu Li), Rhubarb root/rhizome (Da Huang) among others[1][2][3][4][5][6]. Sertraline is a selective serotonin reuptake inhibitor antidepressant that increases synaptic serotonin levels by inhibiting its reuptake in the brain. This combination may be explored for synergistic effects on mood disorders or other neuropsychiatric conditions.

Other names
chai hu jia long gu mu li tang + sertralinebupleurum dragonbone oyster shell teapills + sertraline
02

Targets

SIGMAR1 (Sigma non-opioid intracellular receptor 1)SERT (Sodium-dependent serotonin transporter)

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