buprenorphine + naloxone

Buprenorphine + naloxone is a fixed-dose combination medication used primarily for the treatment of opioid use disorder. Buprenorphine acts as a partial agonist at the μ-opioid receptor, providing enough opioid effect to prevent withdrawal symptoms and cravings but with a ceiling effect that reduces overdose risk. Naloxone is an opioid antagonist included to deter misuse; it has poor oral/sublingual bioavailability but can precipitate withdrawal if injected, discouraging intravenous abuse. The combination is indicated for both induction and maintenance therapy in opioid dependence, reducing mortality associated with opioid use disorder[1][2][3][5][6].

Brand names

SuboxoneZubsolv

Other names

buprenorphine/naloxonebuprenorphine and naloxone