buprenorphine implant

Buprenorphine implant is a subdermal implant containing buprenorphine, a partial opioid agonist. It is designed to provide continuous, non-fluctuating blood levels of buprenorphine for six months after a single insertion procedure. The implant is specifically indicated for the maintenance treatment of opioid dependence in patients who have achieved and sustained prolonged clinical stability on low-to-moderate doses of a transmucosal buprenorphine-containing product (doses of no more than 8 mg per day of Subutex or Suboxone sublingual tablet or equivalent). It should be used as part of a complete treatment program that includes counseling and psychosocial support. The clinical benefits compared to other buprenorphine formulations include improved compliance, reduced risk of diversion, less frequent administration, and continuous, non-fluctuating blood levels for six months. In clinical trials, 63% of Probuphine-treated patients had no evidence of illicit opioid use throughout the six-month treatment period, similar to the 64% of those who responded to sublingual buprenorphine alone.

Brand names

Probuphine