bupropion + trazodone

bupropion + trazodone is a combination of two oral antidepressant medications commonly co-prescribed for the treatment of major depressive disorder, particularly in cases with sleep disturbances or when monotherapy is insufficient. - **Bupropion** is a norepinephrine-dopamine reuptake inhibitor (NDRI) that increases levels of norepinephrine and dopamine in the brain, supporting energy, mood, and attention. - **Trazodone** is a serotonin antagonist and reuptake inhibitor (SARI) that increases serotonin activity and is often used for its sedating effects to improve sleep quality. The combination aims to modulate multiple neurotransmitter systems: bupropion provides activating effects, while trazodone offers sedative and anxiolytic properties. The combined use can improve overall mood and sleep in depression, but requires medical oversight due to the potential for drug interactions (e.g., increased risk of serotonin syndrome, QTc prolongation, neuroleptic malignant syndrome, and cardiovascular or hepatic adverse effects)[1][4]. These two drugs do not have a unique marketed brand as a fixed combination; they are prescribed as individual agents in combination therapy.

Other names

Wellbutrin + trazodone