Drug intelligence / Profile preview

buquinolate

Development stage
Discontinued
Lead developer
Norwich Pharmacal Company
Modality
Small Molecules
Administration
Oral
01

Overview

Buquinolate is a synthetic small molecule belonging to the hydroquinolone class, structurally characterized as a quinoline derivative. It was developed and used as an anticoccidial agent in poultry, specifically for the prevention of coccidiosis in broilers and layers. The drug was approved by the U.S. FDA for this veterinary use but has since been withdrawn from the market[3][4]. Its mechanism of action is presumed to involve inhibition of mitochondrial respiration in Eimeria species (the causative agents of coccidiosis), likely targeting components of the protozoan respiratory chain, similar to other quinolone-based anticoccidials[6]. Medicated birds treated with buquinolate showed improved egg production and weight gain during its period of use[4].

Brand names
BonaidButoril
Other names
buquinolateBuquinolatoBuquinolatumBukhinolyat
02

Targets

bc1 complex (Cytochrome bc1 complex (plasmodium))

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