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Bushen Huoxue Decoction
- Development stage
- Unknown
- Lead developer
- Guang'anmen Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Bushen Huoxue Decoction is a Traditional Chinese Medicine (TCM) herbal formula developed by Guang'anmen Hospital of the China Academy of Chinese Medical Sciences. It is primarily indicated for the treatment of coronary heart disease (CHD) and stable angina pectoris, specifically targeting patients presenting with the TCM syndrome of kidney deficiency and blood stasis. The therapeutic rationale is based on the TCM principles of tonifying the kidney (Bushen) and promoting blood circulation to resolve stasis (Huoxue). It is currently being evaluated in multicenter, randomized, double-blind, placebo-controlled clinical trials to assess its efficacy in reducing angina frequency and improving cardiovascular function.
- Other names
- Bushen Huoxue TangBSHXD
02
Targets
Tumor necrosis factor / Tumor necrosis factor receptor signaling complex (TNF/TNFR signaling complex)Transforming growth factor beta 1 / Mothers against decapentaplegic homolog 2/3 signaling axisPPARG (Peroxisome proliferator-activated receptor gamma)ELANE (Human Neutrophil Elastase)EGFR T790M (Epidermal growth factor receptor T790M mutant)MPO (Myeloperoxidase)RXRA (Retinoid X receptor alpha)
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