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Bushen Huoxue Simiao Formula

Development stage: Phase 4
Lead developer: The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Administration: Oral

Overview

Bushen Huoxue Simiao Formula is a Traditional Chinese Medicine (TCM) herbal composition developed for the management of postoperative complications following surgery for upper urinary tract stones. Specifically, it is used to alleviate symptoms associated with the placement of a double-J stent, such as hematuria, bladder irritation, and flank pain. The formula is designed based on the TCM principles of "Bushen" (tonifying the kidney) and "Huoxue" (invigorating blood circulation) to address the underlying "kidney deficiency" and "blood stasis" believed to occur post-surgery. It is currently being evaluated in Phase 4 clinical trials by The Fourth Affiliated Hospital of Zhejiang University School of Medicine to establish evidence-based efficacy and safety for clinical practice.

Other names: Bushen Huoxue Simiao decoction

Targets

MMP2 (Matrix metalloproteinase-2)MMP9 (Matrix metalloproteinase-9)MAPK14 (p38 mitogen-activated protein kinase alpha)VEGFA (Vascular endothelial growth factor A)JNK (Mitogen-activated protein kinase kinase kinase family)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ESR1 (ERα)LRP6 (Low-density lipoprotein receptor-related protein 6)TLR4 (Toll-like receptor 4)IL-6 (Interleukin 6)

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