Drug intelligence / Profile preview

Bushen Huoxue Yiqi Shengji

Development stage
Preclinical
Administration
Oral
01

Overview

Bushen Huoxue Yiqi Shengji is a traditional Chinese medicine (TCM) multi-herbal formula designed to "tonify the kidney," "benefit qi," and "activate blood circulation." It is used in China for various chronic conditions including heart failure, diabetic retinopathy, diminished ovarian reserve (DOR), hypertensive nephropathy, and as an adjunct in cancer care. The formula typically contains several herbs such as Astragali radix (Huangqi), Angelicae sinensis radix (Danggui), Ligustici Chuanxiong Rhizoma (Chuanxiong), Cuscutae semen (Tusizi), Taxilli Herba (Sangjisheng), Dipsaci Radix (Xuduan) among others[9]. Its mechanism of action involves modulation of inflammatory cytokines and growth factors such as ICAM-1 and VEGF[2], regulation of hormone levels including FSH/LH/E2/AMH[6], improvement of microcirculation and anti-fibrotic effects[1], reduction of advanced glycation end products and HbA1c in diabetes models[2], promotion of angiogenesis via FGF2 upregulation[9], and general immunomodulatory effects. Clinical studies suggest it can improve symptoms or disease markers in heart failure, diabetic retinopathy, diminished ovarian reserve/infertility due to premature ovarian insufficiency or dysfunction, hypertensive nephropathy/chronic kidney disease, osteoporosis/endocrine disorders/lumbar disc herniation/uterine diseases/prostate cancer when used alone or with Western medicine. The precise herbal composition may vary by manufacturer or clinical protocol.

Brand names
Bushen Huoxue Yiqi Shengji
Other names
BYHBYHFBushen Yiqi Huoxue prescriptionBushen Yiqi Huoxue decoctionYiQi HuoXue BuShen decoction
02

Targets

IL-6 (Interleukin 6)IL1B (Interleukin-1 beta)TNFA (Tumor necrosis factor alpha (soluble))VEGFA (Vascular endothelial growth factor A)

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