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Bushen Jianpi Huoxue prescription
- Development stage
- Unknown
- Lead developer
- The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Bushen Jianpi Huoxue prescription is a Traditional Chinese Medicine (TCM) herbal formula developed by The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine. It is specifically designed for the treatment of osteoporosis, particularly in patients exhibiting the TCM syndrome of spleen-kidney yang deficiency. The formula is intended to tonify the kidney, strengthen the spleen, and invigorate blood circulation. In clinical research, it is evaluated in both traditional decoction and modern granule forms, often compared against standard pharmacological treatments like alendronate. Its therapeutic mechanism involves the modulation of bone mineral density (BMD) and bone turnover markers, primarily through the regulation of the RANKL/OPG signaling pathway to inhibit osteoclast-mediated bone resorption and promote bone formation.
- Other names
- Bushen Jianpi Huoxue decoctionBushen Jianpi Huoxue granulesBSJPHX
02
Targets
MAPK3 (Mitogen-activated protein kinase 1)Receptor activator of nuclear factor kappa-B ligand–Receptor activator of nuclear factor kappa-B–Osteoprotegerin signaling axis
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