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Bushen Jianpi Jiedu Recipe is a Traditional Chinese Medicine (TCM) herbal formulation developed by Shuguang Hospital, affiliated with the Shanghai University of Traditional Chinese Medicine. It is specifically investigated for the treatment of HBeAg-negative chronic hepatitis B (CHB). The formulation is based on TCM principles of tonifying the kidney (Bushen), strengthening the spleen (Jianpi), and clearing toxins (Jiedu) to address the underlying deficiency and toxicity associated with chronic viral hepatitis. In clinical trials, it is evaluated as an optimized therapeutic scheme in combination with the nucleoside analog entecavir. The primary goals of this therapy are to enhance HBsAg loss (functional cure), improve immune response, and prevent the progression of liver disease to cirrhosis and hepatocellular carcinoma (HCC).
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