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bushen qianggu decoction
- Development stage
- Unknown
- Lead developer
- China-Japan Friendship Hospital
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Bushen Qianggu decoction is a Traditional Chinese Medicine (TCM) herbal formulation primarily investigated for the treatment of primary osteoporosis. Developed and studied by institutions such as the China-Japan Friendship Hospital, the decoction is designed to "tonify the kidney and strengthen the bone," a core principle in TCM for treating skeletal disorders. It typically contains a mixture of herbs including *Epimedium brevicornu*, *Drynaria fortunei*, and *Rehmannia glutinosa*. Research suggests the formula works by modulating the OPG/RANKL/RANK signaling pathway, thereby promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption. It is frequently evaluated in clinical trials as a combination therapy with standard Western treatments like calcium, vitamin D, and bisphosphonates to improve bone mineral density and reduce fracture risk.
- Other names
- BSQGDBushen Qianggu Tang
02
Targets
RANKL (Receptor Activator for Nuclear Factor-kappa B Ligand)OPG (Osteoprotegerin)
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