Bushen Qingre Runzao Decoction

Bushen Qingre Runzao Decoction is a Traditional Chinese Medicine (TCM) formula developed by the China-Japan Friendship Hospital for the treatment of primary Sjögren's syndrome (pSS). In TCM theory, pSS is often characterized by "Yin deficiency and dryness-heat syndrome," and this decoction is designed to nourish the kidneys (Bushen), clear heat (Qingre), and moisten dryness (Runzao). It is typically administered as an oral decoction. Clinical studies, such as ChiCTR2000037989, have evaluated its efficacy and safety compared to standard treatments like hydroxychloroquine for relieving symptoms such as dry mouth and eyes and improving overall disease status in adult patients.