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Bushen Yisui Formula (BSYSF) is a Traditional Chinese Medicine (TCM) herbal composition designed to 'tonify the kidney and nourish the marrow,' a therapeutic principle used to treat degenerative and inflammatory conditions. In the context of osteoarthritis (KOA), the formula is being investigated by the First Affiliated Hospital of Zhejiang Chinese Medical University for its ability to regulate the epigenetic state of subchondral bone mesenchymal stem cells (MSCs). Specifically, it appears to modulate DNA methylation patterns that influence MSC differentiation into chondrocytes, potentially reversing the pathological changes in the joint environment. While also studied in neuroinflammatory contexts like multiple sclerosis, its application in KOA focuses on subchondral bone remodeling and cartilage repair.
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