Bushen Zhuangjin Decoction

Bushen Zhuangjin Decoction is a **traditional Chinese medicine (TCM) polyherbal formulation** widely used in China for the management of **osteoarthritis (OA)** and related musculoskeletal disorders. It comprises **10 herbal ingredients**: Shu Di Huang (steamed Chinese foxglove, Radix Rehmanniae Glutinosae Conquitae), Dang Gui (Angelica sinensis), Niu Xi (Achyranthes bidentata), Shan Zhu Yu (Cornus officinalis), Fu Ling (Poria cocos), Xu Duan (Dipsacus), Du Zhong (Eucommia bark), Bai Shao (white peony root, Radix Paeoniae Alba), Qing Pi (immature tangerine peel, Pericarpium Citri Reticulatae Viride), and Wu Jia Pi (Acanthopanax root bark)[3][7]. BZD acts through **multifaceted mechanisms**: experimental studies indicate BZD suppresses inflammatory mediators (such as IL-6, IL-1β, TNF-α, and MMPs), **inhibits activation of the NF-κB signaling pathway**, and **prevents chondrocyte apoptosis**, thereby potentially protecting cartilage and supporting joint health[1][3][7]. Key chemical markers include paeoniflorin, morroniside, and asperosaponin VI for quality control[1].

Brand names

Bushen Zhuangjin Decoction

Other names

BZD