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Bushenhuoxue formula
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Bushenhuoxue formula (BSHXF) is a traditional Chinese herbal medicine used primarily for the treatment of knee osteoarthritis (KOA). It is a multi-component decoction that exerts therapeutic effects by regulating chondrocyte survival and inflammatory pathways. Research utilizing network pharmacology and in vivo mouse models (DMM-induced) has demonstrated that BSHXF significantly inhibits apoptosis in joint tissues. This anti-apoptotic effect is mediated through the down-regulation of Caspase-3 (CASP3), Caspase-8 (CASP8), and Caspase-9 (CASP9) expressions. The formula contains numerous active compounds, such as flavonoids and glycosides, which target a broad network of proteins involved in the pathogenesis of osteoarthritis.
- Other names
- Bushen Huoxue decoctionBushen Huoxue recipe
02
Targets
CASP9 (Caspase-9)CASP3 (Caspase-3)CASP8 (Caspase-8)
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