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bushenzhuanggu
- Development stage
- Unknown
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Oral
01
Overview
Bushenzhuanggu refers to a traditional Chinese medicine (TCM) formulation used primarily for the treatment of osteoporosis and bone-related disorders. The name translates as "tonify kidney and strengthen bone," reflecting its TCM principle of nourishing kidney function to support bone health. The formulation is typically available as capsules or pills and may contain a combination of herbal ingredients such as Achyranthes bidentata, which has demonstrated anti-inflammatory, osteogenic, and immune-modulating effects[1][5][8]. Clinical studies have shown that bushenzhuanggu can improve bone mineral density and modulate cytokines related to bone metabolism in patients with primary osteoporosis[6][8][9]. Its mechanism is believed to involve promoting osteoblast activity, enhancing mineralization, reducing inflammation, and regulating immune responses relevant to bone health.
- Brand names
- Bushenzhuanggu capsuleBushenzhuanggu-hwan
- Other names
- Bushen ZhuangguBushen Zhuang Gu补肾壮骨Bushenshugu
02
Targets
HTR1B (5-Hydroxytryptamine Receptor 1B)TPH1 (Tryptophan 5-hydroxylase 1)
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