busulfan + fludarabine + total body irradiation + allogeneic hematopoietic stem cell transplant

This therapeutic regimen, developed by the Masonic Cancer Center at the University of Minnesota, is a reduced intensity conditioning (RIC) protocol designed for patients requiring a second or subsequent allogeneic hematopoietic stem cell transplant (HSCT). It is specifically indicated for individuals with malignant or non-malignant hematologic disorders, hemoglobinopathies, or immunodeficiencies who have failed to achieve adequate donor engraftment or chimerism following a previous transplant. The regimen consists of the alkylating agent busulfan and the purine analog fludarabine, combined with low-dose total body irradiation (TBI). This combination serves to suppress the recipient's immune system and deplete bone marrow niches, facilitating the successful engraftment of infused donor-derived hematopoietic stem cells while minimizing the high toxicity typically associated with standard myeloablative conditioning.

Other names

RIC for Second or Greater Allogeneic HSCTReduced Intensity Conditioning for Second Allogeneic HSCTstem cell transplant-Masonic Cancer Center, University of Minnesota-hematologic disorder-hemoglobinopathy-immunodeficiency