butalbital + caffeine + acetaminophen + codeine

Butalbital + caffeine + acetaminophen + codeine is an oral fixed-dose **small-molecule combination analgesic** indicated for the management of the symptom complex of tension headache when non-opioid analgesics and alternative treatments are inadequate. It combines **butalbital**, a barbiturate with sedative and muscle-relaxant properties; **acetaminophen**, a centrally acting analgesic; **caffeine**, a methylxanthine that can enhance analgesic efficacy; and **codeine**, an opioid agonist that contributes additional pain relief after metabolic conversion to morphine. The combination has historically been marketed as **Fioricet with Codeine** and is also available from generic manufacturers, typically as capsules containing 50 mg butalbital, 325 mg acetaminophen, 40 mg caffeine, and 30 mg codeine phosphate. Because both butalbital and codeine carry risks of addiction, abuse, misuse, medication-overuse headache, and dependence, use is generally reserved for selected patients and repeated or extended use is discouraged.

Brand names

Fioricet with Codeine

Other names

butalbital + caffeine + acetaminophen + codeine phosphatebutalbital, acetaminophen, caffeine, and codeine phosphate capsules