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butaxamine
- Development stage
- Unknown
- Lead developer
- Hoechst
- Modality
- Small Molecules
- Administration
- Intraperitoneal, Intravenous, Oral, Subcutaneous
01
Overview
Butaxamine (also known as butoxamine) is a selective beta-2 adrenergic receptor (ADRB2) antagonist. Originally developed by Burroughs Wellcome and Hoechst, it is primarily utilized as a research tool in pharmacological and physiological experiments to characterize beta-adrenergic receptor subtypes and investigate the role of ADRB2 in various biological processes. In preclinical studies, butaxamine has been investigated for its potential antiosteoporotic activity, its effects on bone metabolism, and its role in modulating the tumor-neuroimmune network in triple-negative breast cancer (TNBC) under chronic stress. It has no approved clinical indications and is not marketed for human use.
- Other names
- alpha-(1-(tert-butylamino)ethyl)-2,5-dimethoxybenzyl alcoholbutaxamine hydrochloridebutoxaminebutoxamine hydrochloride
02
Targets
ADRB2 (β2)
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