Drug intelligence / Profile preview

buyang huanwu decoction + wuling powder

Development stage
Unknown
Lead developer
Liaoning University of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Buyang Huanwu Decoction + Wuling Powder is a combination of two classical Traditional Chinese Medicine (TCM) herbal formulas being investigated as an adjunctive therapy for acute ischemic stroke. Buyang Huanwu Decoction (BHD) is a well-known prescription composed of seven herbs (including Astragali Radix and Angelicae Sinensis Radix) traditionally used to treat stroke-induced disability and neurological impairment. Wuling Powder is a classical diuretic and water-regulating formula. This multi-component botanical therapy is thought to exert neuroprotective effects by modulating multiple biological pathways, including neuroinflammation, oxidative stress, apoptosis, angiogenesis, and ferroptosis. Specifically, it has been shown to interact with targets such as EGFR, HSP90AA1, and GRB2, and influence the PI3K-Akt and MAPK signaling pathways. It is currently being evaluated in clinical trials sponsored by Liaoning University of Traditional Chinese Medicine to improve neurological function and activities of daily living in stroke patients.

Other names
BHD + WLPBuyang Huanwu Decoction Combined With Wuling PowderBuyang Huanwu Decoction and Wuling Powder
02

Targets

VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFA (Vascular endothelial growth factor A)MAPK3 (Mitogen-activated protein kinase 1)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)HSP90AA1 (Heat shock protein HSP90-alpha)GRB2 (Growth factor receptor-bound protein 2)EGFR T790M (Epidermal growth factor receptor T790M mutant)

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