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Buzhong Tiaogan Formula
- Development stage
- Unknown
- Lead developer
- Shanxi Provincial Hospital of Traditional Chinese Medicine
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Oral
01
Overview
Buzhong Tiaogan Formula (BTF) is a traditional Chinese medicine (TCM) herbal combination developed and used primarily for the prevention and treatment of colorectal cancer liver metastasis, particularly in patients with the "liver depression spleen deficiency" pattern as defined by TCM. The formula is being evaluated in clinical trials for its efficacy in delaying the occurrence of colorectal liver metastasis when used alongside standard antitumor therapies. Its mechanism of action, according to traditional theory, involves regulating Qi (vital energy), supporting spleen function, harmonizing liver function, and improving immune status. Modern research aims to assess its impact on quality of life, time to metastasis development, tumor microenvironment modulation, and immune state improvement[1]. The specific herbal composition may differ from classic formulas such as Bu Zhong Yi Qi Tang; however, it is based on similar principles—tonifying middle Jiao Qi (spleen/stomach), regulating Qi flow between the liver and spleen systems.
- Brand names
- Buzhong Tiaogan Formula
- Other names
- BTF
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)TNFA (Tumor necrosis factor alpha (soluble))MMP9 (Matrix metalloproteinase-9)IL-6 (Interleukin 6)
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