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Buzhong Yiqi granule is a Traditional Chinese Medicine (TCM) formulation based on the classic "Buzhong Yiqi Tang" formula, which was first documented in the 13th-century text "Treatise on the Spleen and Stomach." The formulation typically consists of eight herbs, including *Astragalus membranaceus*, *Glycyrrhiza uralensis*, *Panax ginseng* (or *Codonopsis pilosula*), *Atractylodes macrocephala*, *Angelica sinensis*, *Cimicifuga foetida*, *Bupleurum chinense*, and *Citrus reticulata*. Its primary pharmacological actions are to tonify the middle jiao, benefit Qi, and lift "sunken Yang." In modern clinical research, particularly studies conducted by The First Affiliated Hospital of Gannan Medical University, it has been investigated for its efficacy in treating postpartum stress urinary incontinence (SUI) associated with Qi deficiency syndrome. The mechanism of action involves improving the structural integrity and functional tension of the pelvic floor muscles and urethral sphincter, potentially through the modulation of inflammatory cytokines and interaction with estrogen receptors.
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