Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
BV GA733-2E
- Development stage
- Unknown
- Lead developer
- The Wistar Institute
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
BV GA733-2E is a recombinant protein cancer vaccine consisting of the extracellular domain of the GA733-2 antigen, which is also known as EpCAM (Epithelial Cell Adhesion Molecule), CO17-1A, or KSA. The protein is expressed using a baculovirus (BV) vector system. It was developed as an active immunotherapy for colorectal carcinoma (CRC) to induce both humoral (antibody) and cellular (T-cell) immune responses against tumor cells expressing the GA733-2 antigen. Unlike anti-idiotypic antibodies that mimic a single epitope, BV GA733-2E contains multiple potentially immunogenic epitopes of the extracellular domain. In clinical trials, it has been administered with aluminum hydroxide as an adjuvant.
- Other names
- GA733-2EGA-733-2EGA 733-2Ebaculovirus-expressed GA733-2 extracellular domainrecombinant EpCAM extracellular domainrecombinant GA733-2 extracellular domain
Beyond the preview
Go deeper on BV GA733-2E.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on BV GA733-2E.