BV6

BV6 is a bivalent small-molecule Smac (Second Mitochondria-derived Activator of Caspases) mimetic that functions as a potent antagonist of Inhibitor of Apoptosis Proteins (IAPs), including cIAP1, cIAP2, and XIAP. By mimicking the N-terminal IAP-binding motif of mature Smac, BV6 induces the rapid proteasomal degradation of cIAPs and prevents XIAP from inhibiting caspases-3, -7, and -9. This action sensitizes cancer cells to apoptosis induced by death receptor ligands (such as TNFα or TRAIL) and various chemotherapeutic agents. BV6 is widely used as a pharmacological tool to study necroptosis and apoptosis pathways, particularly in the context of overcoming chemoresistance in malignancies such as glioblastoma, ovarian cancer, and leukemia.

Other names

Smac mimetic BV6bivalent Smac mimetic BV6