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BW-00163

Development stage: Unknown
Lead developer: Novartis
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Subcutaneous

Overview

BW-00163 is a GalNAc-conjugated small interfering RNA (siRNA) designed to target and degrade angiotensinogen (AGT) mRNA in the liver. Developed by Hangzhou Bolin Pharmaceutical (Bolin Pharma), the drug utilizes a N-acetylgalactosamine (GalNAc) delivery platform to ensure highly specific uptake by hepatocytes. By silencing the expression of AGT, the sole precursor of all angiotensin peptides, BW-00163 provides a long-lasting inhibition of the renin-angiotensin-aldosterone system (RAAS). This mechanism is intended to provide sustained blood pressure control with infrequent dosing (potentially quarterly or biannually) for patients with hypertension. It is currently in Phase 1 clinical development in China.

Targets

AGT (O6-methylguanine-DNA methyltransferase)

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