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BW-20805

Development stage: Phase 2
Lead developer: Shanghai Argo Biopharmaceutical
Modality: Small Molecules, Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Subcutaneous

Overview

BW-20805 is a next-generation small interfering RNA (siRNA) therapeutic under development by Argo Biopharma for the treatment of hereditary angioedema. The drug targets plasma kallikrein (PKK), inhibiting its expression through RNA interference, thereby reducing the production of proteins involved in the disease process. It is administered as a subcutaneous injection and is currently in Phase I clinical trials. The drug leverages Argo Biopharma's proprietary RADS platform technology for enhanced activity, durability, and safety[1][2][6][7].

Other names: PKK siRNA

Targets

PKK (Plasma prekallikrein (KLKB1))

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