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BW-41012

Development stage: Phase 1
Lead developer: Shanghai Argo Biopharmaceutical
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Subcutaneous

Overview

BW-41012 is an investigational small interfering RNA (siRNA) therapeutic developed by Shanghai Argo Biopharmaceutical for the prevention and treatment of thrombotic disorders. It is designed to target and silence the expression of Coagulation Factor XI (FXI) in the liver. By reducing FXI levels, BW-41012 aims to inhibit the intrinsic pathway of coagulation, potentially offering a safer profile with a reduced risk of bleeding compared to conventional anticoagulants like warfarin or direct oral anticoagulants (DOACs). The drug is administered subcutaneously and is currently being evaluated in Phase 1 clinical trials for safety, tolerability, and pharmacodynamics.

Targets

F11 (Coagulation Factor XI)FXI (Coagulation factor XI)

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