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BWA-03

Development stage: Preclinical
Lead developer: Shanghai Argo Biopharmaceutical
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Subcutaneous

Overview

BWA-03 is a small interfering RNA (siRNA) therapeutic candidate under development by Argo Biopharma (also known as Chengdu Xinzhenghe Pharmaceutical Technology) for the treatment of obesity. As an RNA interference (RNAi) therapy, BWA-03 is designed to achieve long-lasting gene silencing of a specific metabolic target involved in the regulation of body weight and energy homeostasis. The program utilizes Argo's proprietary RNAi platform, which typically employs GalNAc-conjugation to ensure targeted delivery to hepatocytes. BWA-03 is currently in the preclinical stage of development and is intended for subcutaneous administration, potentially offering a potent and durable alternative to existing weight-loss therapies through infrequent dosing.

Other names: BWA-03BWA03BWA 03

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