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Byondis (formerly Synthon Biopharmaceuticals) is developing a platform for masked, conditionally activated antibodies and antibody-drug conjugates (ADCs) for the treatment of various cancers. These therapeutics are designed to remain inactive in systemic circulation and become selectively activated within the tumor microenvironment, typically through cleavage by tumor-specific proteases or other local biochemical triggers. This approach aims to enhance the therapeutic index by reducing off-target toxicity while maintaining potent anti-tumor activity. The specific targets and lead candidates within this preclinical program remain undisclosed.
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