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Byondis masked antibody-drug conjugate

Development stage
Preclinical
Lead developer
Byondis
Modality
Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

Byondis (formerly Synthon Biopharmaceuticals) is developing a platform for masked, conditionally activated antibodies and antibody-drug conjugates (ADCs) for the treatment of various cancers. These therapeutics are designed to remain inactive in systemic circulation and become selectively activated within the tumor microenvironment, typically through cleavage by tumor-specific proteases or other local biochemical triggers. This approach aims to enhance the therapeutic index by reducing off-target toxicity while maintaining potent anti-tumor activity. The specific targets and lead candidates within this preclinical program remain undisclosed.

Other names
Synthon Biopharmaceuticals-undisclosed-antibody-ADC-oncology
02

Targets

MET (Mesenchymal-epithelial transition factor receptor)

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