Drug intelligence / Profile preview

BYSH + saw palmetto

Development stage
Unknown
Lead developer
China Medical University
Modality
Small Molecules
Administration
Oral
01

Overview

BYSH + saw palmetto is an investigational combination therapy comprising the Traditional Chinese Medicine (TCM) formula Bu-Yuan-Sheng-Hui (BYSH) and the botanical extract saw palmetto (*Serenoa repens*). This combination was specifically developed and evaluated for the treatment of hormone-refractory prostate cancer (HRPC), also known as castration-resistant prostate cancer. Saw palmetto acts primarily by inhibiting 5-alpha-reductase, the enzyme responsible for converting testosterone into the more potent androgen dihydrotestosterone (DHT), and may also possess direct anti-proliferative and anti-inflammatory properties within the prostate. BYSH is a multi-herb TCM decoction designed to tonify Qi and Yang, which in a clinical oncology context is intended to enhance immune function, improve quality of life, and potentially exert synergistic anti-tumor effects. The combination represents an integrative approach to managing advanced prostate cancer by targeting both the endocrine drivers of the disease and the patient's overall physiological resilience.

Other names
Bu-Yuan-Sheng-Hui plus saw palmettoBYSH + Serenoa repensBu-Yuan-Sheng-Hui plus Serenoa repens
02

Targets

SRD5A2 (Steroid 5-alpha-reductase type II)AR (Adrenergic receptors)SRD5A1 (Steroid 5-alpha-reductase type 1)

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